Holmes, Margaret and Poe run the private detective agency that solves the crimes no one else can. Or they did – until Holmes said he wanted to leave the business and fell off the radar. In New York City, they are called to investigate the abduction of six newborns from a private hospital. Without Holmes, they try to investigate this terrible crime. They hear word of more missing babies in London, and Margaret follows the trail across the pond. But they need Holmes. To solve the crime of the century, first they must save their friend.